Cyclosporine Soft Gel Capsules

Cyclosporine Soft Gel Capsules

74 INR/Box

Product Details:

  • Drug Type General Medicines
  • Ingredients glycerin, glyceryl caprylate,
  • Physical Form Capsules
  • Suitable For Adults
  • Storage Instructions Cool and Dry Place
  • Click to view more
X

Cyclosporine Soft Gel Capsules Price And Quantity

  • 74 INR/Box
  • 300 Box

Cyclosporine Soft Gel Capsules Product Specifications

  • General Medicines
  • Cool and Dry Place
  • Adults
  • glycerin, glyceryl caprylate
  • Capsules

Cyclosporine Soft Gel Capsules Trade Information

  • Cash in Advance (CID) Cash Advance (CA)
  • 300 Box Per Month
  • 1 Months
  • Yes
  • Sample costs shipping and taxes has to be paid by the buyer
  • Western Europe Asia Australia Middle East Central America Eastern Europe South America North America Africa
  • All India

Product Description

Cyclosporine lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader.Cyclosporine is used to prevent organ rejection after a kidney, heart, or liver transplant. Cyclosporine is also used to treat severe psoriasis or severe rheumatoid arthritis.

Pharmacology:

Pharmacodynamic Properties Of Cyclosporine
Used in immunosuppression for prophylactic treatment of organ transplants, cyclosporine exerts specific and reversible inhibition of immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited. The T1-helper cell is the main target, although the T1-suppressor cell may also be suppressed. Sandimmune (cyclosporine) also inhibits lymphokine production and release including interleukin-2.
Pharmacokinetic Properties Of Cyclosporine
  • Absorption:
    The absorption of cyclosporine from the gastrointestinal tract is incomplete and variable. The extent of absorption is dependent on the individual patient, the patient population, and the formulation.
  • Protein Binding:
    In the plasma, approximately 90% is bound to proteins, primarily lipoproteins. In blood, the distribution is concentration dependent. Approximately 33% to 47% is in plasma, 4% to 9% in lymphocytes, 5% to 12% in granulocytes, and 41% to 58% in erythrocytes.
  • Metabolism:
    Hepatic, extensively metabolized by the cytochrome P450 3A enzyme system in the liver. It is also metabolized in the gastrointestinal tract and kidney to a lesser degree. The metabolites are significantly less potent than the parent compound. The major metabolites (M1, M9, and M4N) result from oxidation at the 1-beta, 9-gamma, and 4-N-demethylated positions, respectively.
  • Route Of Elimination:
    Elimination is primarily biliary with only 6% of the dose (parent drug and metabolites) excreted in the urine. Only 0.1% of the dose is excreted in the urine as unchanged drug.
Pregnancy & Lactation
Pregnancy Pregnant women receiving immunosuppressive therapies after transplantation, including cyclosporin and cyclosporin-containing regimens, are at risk of premature delivery.
Breast-Feeding Cyclosporin passes into breast milk. The ethanol content of the Neoral formulations should also be taken into account in women who are breast-feeding
Contraindications
Hypersensitivity to the active substance or to any of the excipients.
Side Effects
Very rare but the common side effects are:
Shaking
Headache
Dizziness
Unusual growth of body hair,
Nausea/vomiting
Diarrhea
Stomach upset

Tell us about your requirement
product

Price:

Quantity
Select Unit

  • 50
  • 100
  • 200
  • 250
  • 500
  • 1000+
Additional detail
Mobile number

Email

Other Products in 'Soft Gelatin Capsules' category



Back to top