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Thiocolchicoside Capsule
76 INR/Box
Product Details:
- Drug Type General Medicines
- Physical Form Capsules
- Suitable For Adults
- Storage Instructions Cool and Dry Place
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Thiocolchicoside Capsule Price And Quantity
- 300 Box
- 76 INR/Box
Thiocolchicoside Capsule Product Specifications
- Cool and Dry Place
- General Medicines
- Capsules
- Adults
Thiocolchicoside Capsule Trade Information
- Cash in Advance (CID) Cash Advance (CA)
- 300 Box Per Month
- 1 Months
- Yes
- Sample costs shipping and taxes has to be paid by the buyer
- Australia South America Middle East Western Europe Asia Central America Eastern Europe North America Africa
- All India
Product Description
Thiocolchicoside, is a synthetic sulphur derivative of colchicoside, a naturally occurring glucosidecontained in theColchicum autumnale plant Thiocolchicoside has a selective affinity for g-amino-butyric acid (GABA) receptors and actson themuscular contracture by activating the GABA-nergicinhibitory pathways thereby acting as a potent mus-clerelaxant Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects. Itacts as a competitive GABAA receptor antagonist and also inhibits glycine receptors with similar potency and nicotinicacetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizureproneindividuals. Mode of action includes modulation of chemokine and prostanoid production and inhibition ofneutrophil and endothelial cell adhesion molecules by which it interferes with the initiation and amplification of the jointinflammation.Indications:
Backache, Neuralgia, Pain, Parkinsonism, Sciatic pain.
Contraindications:
Thiocolchicoside is contraindicated in conditions like Flaccid paralysis, Muscular hypotonia.
Pharmacokinetics:
Thiocolchicoside is a muscle relaxant which has been claimed to possess GABA-mimetic and glycinergic actions.
Pharmacology:
Potent competitive antagonist of GABA function.
A muscle relaxant and displays anti-inflammatory and analgesic propertiesFollowing oral administration, thiocolchicoside is well absorbed from the gastrointestinal tract.
It shows its effect in 1-2 hours after oral administration and peak plazma level is achieved in about 0.7 hoursElimination half-life is about 2.5-5 hours. Its effect is continued for 24 hours.
Adverse Effects:
Most of adverse reactions observed in clinical trials were of a mild and transient nature. The most commonly seen adverse reactions in clinical trials of the tablet formulation were gastrointestinal and also adverse reaction have been reported for cephalosporin sensitive person and also in some cases somnolence, nasopharyngitis, fatigue, dry mouth and pharyngitis, and most were mild to moderate in intensity.
Side Effects:
The symptomatic adverse reactions produced by Thiocolchicoside are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea.
Storage :
Store in a cool dry place. Protect from light.
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Contact Details
STUDIUM FORMULATIONS
GST : 24AHLPV3477E1Z0
GST : 24AHLPV3477E1Z0
- 1st Floor, Plot No 16-B, C/o Kush Industries, Vapi - 396191, Gujarat, India
- Phone :08037802955
Send Inquiry- Manufacturing Unit 01: SR. No. 121, Plot No 13, Evershine Industrial Area, Chirri, Vapi, Gujarat - 396195
Manufacturing Unit 02:AUGUSTO FORMULATIONS PRIVATE LIMITED
Gala 4,5,6, Ground Floor ,Building No. A ,UNIT 2 Survey No.906/2,
Krishna Industrial Estate, Amli, Silvassa, Dadra & Nagar Haveli,
Daman & Diu- 396230
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